ENGINEERING
HEALTHY BEHAVIOR
THE SCIENCE OF RESILIENCE
THE GENOMICS
OF WELL-BEING

RESEARCH CONNECTING MIND, BODY, & HUMAN HEALTH

Science is integral to all of HopeLab’s work – from the creation of behavior change interventions such as Re-Mission and Zamzee to new technology solutions for the Nurse-Family Partnership and Stanford’s Adolescent & Young Adult Cancer Program. We harness scientific insight to promote the health of kids and young adults.

Discovery Science: exploring basic connections between social processes, human behavior, neuroscience, and the human genome. Examples include:

  • molecular impact of purpose, social connection, & prosocial behavior,
  • neural mechanisms of motivation and behavior change,
  • genomic biomarkers of well-being.

Translational Science: translating discovery insights into technology products for broad impact. This research includes:

  • product development / human-centered design / engineering behavior change,
  • psychological market analysis,
  • randomized controlled impact trials.
Nelson et al., 2016 EMOTION
Cole – Human Social Genomics – PLOS Genetics 2014
Eisenberger & Cole – Soc Neurosci & Health – Nature Neurosci 2012 ePub
Pediatrics_ReMission
Cole – Soc Reg Human Gene Exp – Am J Pub Health 2013
Loneliness, Eudaimonia & Gene Expression in HRS – PNE 2015
journal.pone.0033909
Slavich – Human Social Genomics – Clin Psych Sci 2013
Black et al – Meditation & Gene Expression – PNE 2012
Cole – TOA Isolation & Myeloid APCs – PNAS 2011
Social relationships and mortality – Holt-Lundstadt et al PLoS Med 2010
White Paper: Landscape Analysis of Youth, Technology, & Health
Social Regulation of Gene Expression – Genome Biology 2007
RuckusResearch_slideshow
Cole – Social Isolation & Myeloid Population Dynamics – PNAS 2015
Psychological Resilience and the Gene Regulatory Impact of Posttraumatic Stress in Nepali Child Soldiers
journal.pone.0128639
Social & Emotional Learning and Teacher Education: What do we know and where do we go from here?
Bower MAPS RCT & Gene Expression – Cancer 2015
Fredrickson – Eudaimonia & CTRA – PLOS ONE 2015
Cacioppo – Neuroendocrinology of Social Isolation – Ann Rev Psych 2015
Irwin – TCC inflammation insomnia – JNCI Monographs 2014
Bower Yoga RCT & Gene Expression – PNE 2014
Fredrickson – Wellbeing & Gene Expression – PNAS 2013
Chen et al – Helping Others & CV risk -JAMA Peds 2013
Creswell MBSR Loneliness & Gene Expression – BBI 2012
Irwin Cole – Neural & innate immune – Nat Rev Immunol 2011
Creswell MBSR Loneliness & Gene Expression – BBI 2012

Research Leadership

Dr. Steve Cole leads HopeLab’s research and development efforts. As a biomedical scientist, his research analyzes the biological pathways through which social and psychological processes influence gene expression in the human immune system, viruses, and cancer. As a behavioral scientist, he guides HopeLab’s technology development strategy to promote human health and behavior change. Dr. Cole also serves as Professor of Medicine in the Division of Hematology-Oncology at UCLA and was a founding member of the HopeLab team.

Research Partners

Mark Brackett, Ph.D.
Director of the Yale Center for Emotional Intelligence
Visit Site
Mood Meter
"If you want to translate research concepts into digital experiences that have a positive impact on the world, then HopeLab is the place to go. They’re stellar human beings, brilliant and creative."
— Mark Brackett, Ph.D.
Stephanie Jones, Ph.D.
Associate Professor, Human Development & Urban Education
Visit Site
Ready to Learn
"Working with HopeLab, the EOC, and the teachers in South Carolina has been a wonderful experience. We’ve been able to refine and optimize Brain Games to fit the lives of teachers and schools with the help of HopeLab’s user-centered design process. I’m excited to continue to use and study Brain Games in future projects and collaborations, with the ultimate goal of improving students’ skills for learning and life."
— Stephanie Jones, Ph.D.
Brandon Kohrt
Assistant Professor of Psychiatry
Visit Site
Resilience In Nepali Child Soldiers
"HopeLab stands apart from other organizations dedicated to advancing youth health and wellbeing. They provide conceptual and theoretical framing support informed by their team’s research on topics ranging from social genomics to child education to cross-cultural child development. Their expertise is provided to broaden the scope and societal impact of the projects that HopeLab supports. Most importantly, they have a global vision to support resilience among youth, from urban U.S. cities to rural villages of Nepal."
— Brandon Kohrt
Sarah Konrath, Ph.D.
Assistant Professor of Psychology
Visit Site
Text to Connect
"I like HopeLab’s approach to philanthropy, which goes beyond the simple giver-receiver dynamic and magnifies their giving because it teaches their research partners new skills in the context of an active project. These new skills for us included learning about how to conduct early stage and iterative user testing. It’s silly to design the perfect theoretically based intervention without hearing from the target group who will be using it. Having input early on from that group can make interventions stickier in the real world."
— Sarah Konrath, Ph.D.
David Yeager, Ph.D.
Assistant Professor of Developmental Psychology
Visit Site
A Growth Mindset Intervention
"There isn't a group that knows and cares about young people and their thriving and success more than HopeLab. The fact that they combine that ethos with world-leading expertise in design is truly awe-inspiring. The team is comprised of superstar designers. The spirit of learning and improvement is baked into everything they do. And they deliver amazing insights and products. But it’s all in the service of a question: how can we help young people be resilient?  It’s an honor and privilege to learn from and with the amazing team at HopeLab."
— David Yeager, Ph.D.
Brad Zebrack, Ph.D.
Professor of Social Work at University of Michigan
Visit Site
Resilience in Cancer Patients and Survivors
"HopeLab has made an important impact on AYA survivorship—through the Re-Mission videogames and also their investment in scientific research that examines and promotes human resilience to cancer."
— Brad Zebrack, Ph.D.

Collaborate With Us

Learn more about how we work with research partners.